Albendazole has been in clinical use in humans for around 30 years and is a well-established anti-parasitic treatment with a broad spectrum of activity against cestodes (i.e. Since the introduction of benzimidazole drugs in the 1960s, they have been used broadly in a wide range of species for the control of parasitic helminths. Benzimidazoles derivatives are characterised by multicompartment and ambiguous pharmacokinetic models. Applying UV-Vis spectrometry we here demonstrate ABZ as a DNA intercalator. Pancreatic cancer (PC) is one of the most lethal, chemoresistant malignancies and it is of paramount importance to find more effective therapeutic agents. Repurposing of non-anticancer drugs may expand the repertoire of effective molecules. Search for more papers by this author. Flubendazole: Flubendazole is an anthelmintic that is used to treat worm infection in humans. The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. echinococcosis) as well as intestinal and tissue nematodes. Medicinal Chemistry Research 2016 , 25 (2) , 173-210. The benzimidazoles (albendazole, mebendazole) are the only drugs available for drug treatment of CE. Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. A benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. Pharmacokinetic properties of benzimidazole derivatives drug possessing antipsychotic, actoprotector, antiarrhythmic, antiulcerogenic, antiallergic, uricosuric, anthelmintic activities have been summarized. This insight led us to determine the primary mode of ABZ action in mammalian cells. In using anthelmintic combinations or rotations, consideration should be given to the genetic interactions in the parasite between benzimidazole and macrocyclic lactone anthelmintics in terms of selection for the alleles that confer benzimidazole resistance. These anthelmintic compounds inarguably have the most extensive therapeutic effect against diverse parasites species, excellent anti-parasitic efficacy, and low toxicity in treated animals. Benzimidazole anthelmintic drugs. The benzimidazole anthelmintic agents‐a review. Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow G61 1QH, UK. Pharmacokinetics of benzimidazole derivatives used in veterinary practice as anthelmintic drugs is also considered. Pharmacokinetics of benzimidazole derivatives used in veterinary practice as anthelmintic dru … E. W. SCOTT. A. McKELLAR. Q. Due to their low cost and high efficacy, benzimidazole anthelmintics have been used throughout the world since their introduction in the 1960s ( 1 ). It is available OTC in Europe. Benzimidazoles • Inhibition of fumarate reductase system • Glucose uptake Members • Thiabendazole • Albendazole • Cambendazole • Fenbendazole • Mebendazole • Oxfendazole (R.T.L) • Oxibendazole (R) • Panbendazole Benzimidazole pro-drugs • Febental – Fenbendazole • Netobimin - … Benzimidazole anthelmintics have a chemical structure of benzimidazole with broad anthelmintic activity and are extensively used in both human and veterinary medicine to control internal parasites. Benzimidazoles have efficacy on E granulosus and E multilocularis larval stages. Mebendazole (MBZ) and albendazole (ABZ) are the only benzimidazoles effective in experimental models, but their efficacy is related to the clinical condition. Studies on repurposing of benzimidazole-based anthelmintics in PC and on their interaction with agents approved for PC therapy are lacking. Class Summary.